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iwp 2 wnt inhibitor  (MedChemExpress)


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    MedChemExpress iwp 2 wnt inhibitor
    Iwp 2 Wnt Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 55 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/iwp+2+wnt+inhibitor/IWP-2/pmc13156600-287-77-81
    Average 95 stars, based on 55 article reviews
    iwp 2 wnt inhibitor - by Bioz Stars, 2026-09
    95/100 stars

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    Article Title: Systems genetics reveals ITIH5 as a key mediator of adipocyte–Endothelial crosstalk
    Article Snippet: .. Thereafter the media was changed every 2–3 days until cells reached ∼90% confluency at which time the ASC harvest media was removed and replaced with ASC differentiation media – Harvest media spiked with 33 μM biotin (Sigma–Aldrich), 17 μM d -pantothenate (Sigma–Aldrich), 1 μM dexamethasone (Sigma–Aldrich), 5 μM rosiglitazone (Sigma–Aldrich), 500 μM methylisobutylxanthine (Sigma–Aldrich), 100 nM insulin (Sigma–Aldrich) – and left for 3 days in one of four groups: control, 100 ng/mL + itih5 (OriGene), 5 μM + IWP-2 Wnt inhibitor (MedChemExpress) or + itih5 and IWP-2 Wnt inhibitor. ..

    Article Title: Systems Genetics Reveals ITIH5 as a Key Mediator of Adipocyte-Endothelial Crosstalk.
    Article Snippet: .. Thereafter the media was changed every 2-3 days 513 until cells reached ~90% confluency at which time the ASC harvest media was removed and 514 replaced with ASC differentiation media – Harvest media spiked with 33μM biotin (Sigma-515 Aldrich), 17μM D-pantothenate (Sigma-Aldrich), 1μM dexamethasone (Sigma-Aldrich), 5μM 516 rosiglitazone (Sigma-Aldrich), 500μM methylisobutylxanthine (Sigma-Aldrich), 100nM insulin 517 (Sigma-Aldrich) – and left for 3 days in one of four groups: control, 100ng/mL +itih5 (OriGene), 518 5μM +IWP-2 Wnt inhibitor (MedChemExpress) or +itih5 and IWP-2 Wnt inhibitor. ..



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    HA-induced activation of the canonical Wnt pathway upregulates FOSL2 to expand the dNK1-like subpopulation. (A) Analysis of transcriptional activity and expression levels of transcription factors in three dNK subsets using scRNA-seq data from normal decidual tissue ( n = 11). (B) Transcriptional activity and expression levels of FOSL2 in decidual tissues from normal pregnancy ( n = 5) and RSA groups ( n = 3). (C) Changes in NK92MI cells of the five transcription factors ( STAT3, MAFB, HES1, FOSL2, ETV5 ) characterized by high transcriptional activity and expression in the dNK1 subset following HMW-HA treatment, as determined by RT−qPCR ( n = 6 per group). (D) FOSL2 expression in NK92MI cells following HMW-HA treatment, assessed by WB ( n = 3 per group). (E) Wnt1 and β-catenin protein expression in NK92MI cells treated with or without HMW-HA in the presence or absence of CD44 blockade ( n = 3 per group). (F) FOSL2 expression in HA−treated NK92MI cells after addition of CD44−blocking antibody or the Wnt pathway inhibitor IWP−2 to the culture system ( n = 3 per group). Data are expressed as mean ± SD; * P < 0.05; ** P < 0.01; ns, not significant. EP, early pregnancy; SA, spontaneous abortion; RSA, recurrent spontaneous abortion.

    Journal: Frontiers in Immunology

    Article Title: Hyaluronic acid−CD44 signaling from decidual stromal cells orchestrates dNK1 differentiation and immune tolerance in early pregnancy

    doi: 10.3389/fimmu.2026.1777567

    Figure Lengend Snippet: HA-induced activation of the canonical Wnt pathway upregulates FOSL2 to expand the dNK1-like subpopulation. (A) Analysis of transcriptional activity and expression levels of transcription factors in three dNK subsets using scRNA-seq data from normal decidual tissue ( n = 11). (B) Transcriptional activity and expression levels of FOSL2 in decidual tissues from normal pregnancy ( n = 5) and RSA groups ( n = 3). (C) Changes in NK92MI cells of the five transcription factors ( STAT3, MAFB, HES1, FOSL2, ETV5 ) characterized by high transcriptional activity and expression in the dNK1 subset following HMW-HA treatment, as determined by RT−qPCR ( n = 6 per group). (D) FOSL2 expression in NK92MI cells following HMW-HA treatment, assessed by WB ( n = 3 per group). (E) Wnt1 and β-catenin protein expression in NK92MI cells treated with or without HMW-HA in the presence or absence of CD44 blockade ( n = 3 per group). (F) FOSL2 expression in HA−treated NK92MI cells after addition of CD44−blocking antibody or the Wnt pathway inhibitor IWP−2 to the culture system ( n = 3 per group). Data are expressed as mean ± SD; * P < 0.05; ** P < 0.01; ns, not significant. EP, early pregnancy; SA, spontaneous abortion; RSA, recurrent spontaneous abortion.

    Article Snippet: To determine the signaling pathways involved, we used an anti-CD44 blocking antibody (30 μg/mL; BioxCell, BE0262) to block CD44, and IWP-2 (50 μM; MedChemExpress, HY-13912) to inhibit the canonical Wnt pathway.

    Techniques: Activation Assay, Activity Assay, Expressing, Quantitative RT-PCR, Blocking Assay